![]() |
source:wikimedia |
The term “walking pneumonia” sounds like a scary term. Though this type of
pneumonia could make an individual miserable, it is really the least scariest
type of pneumonia. That is due to it being a pneumonia that is mild and
doesn’t usually need any hospitalization. Indeed, you might possess this type
of pneumonia and not even realize it.
What exactly is this term walking pneumonia?
This type of pneumonia describes a mild instance of pneumonia. Additionally,
this could be referred to as atypical pneumonia due to the disease varying
from the more serious pneumonia instances which are caused by some typical
bacteria.
A disease of the lungs, pneumonia oftentimes results from a lung infection. A
lot of things could trigger pneumonia, involving:
-bacteria
-additional infectious agents, like mycoplasma
-inhaled food
-viruses
-fungi
-chemicals
Walking pneumonia will oftentimes be the result of a lung infection from
Mycoplasma pneumoniae, a bacterial microorganism.
Individuals who possess walking pneumonia will seldom be confined to a bed or
require hospitalization. A few individuals might be feeling well enough to go
to their job and continue with their standard routine, just like they would
when they have a common cold.
How’s it spread and who can obtain this type of pneumonia?
Anybody at all ages could obtain walking pneumonia, though this type of
pneumonia from mycoplasma pneumoniae will be more popular within older kids
and adults who are younger than forty years old.
Individuals who work and live within crowded places, like homeless shleters,
prisons and schools have a larger risk of obtaining this disease. That is due
to walking pneumonia being contagious. It is spread as somebody comes within
touch with droplets from the throat and nose of somebody who possesses it.
This usually occurs as an individual who has walking pneumonia coughs or
sneezes.
Instances of this type of pneumonia are more popular within the late fall and
summer. Yet, infections could happen with no specific pattern through the
year. Although this disease will be contagious, it’ll spread very slowly. A
contagious duration within most instances will last under ten days.
Researchers additionally believe it takes a long period of close contact with
the infected individual for somebody else to get walking pneumonia; but still,
there includes widespread outbreaks each 4 to 8 years. As those outbreaks
happen, walking pneumonia accounts for as much as 1 out of each 2 pneumonia
instances.
Mycoplasma Pneumoniae in Children
![]() |
source:flickr |
Located within the throats of the infected people, mycoplasma includes a
contagious bacterium which might lead to your kid experiencing a whole range
of respiratory complications and symptoms after infection. Familiarizing
yourself with some facts concerning mycoplasma infection within children can
assist you in reducing your child’s opportunities of obtaining this type of
health condition. Crowded group tasks within schools can contribute to the
youngster’s risk of getting mycoplasma.
Facts
Commonly referred to as mycoplasma, the bacteria Mycoplasma pneumoniae could
lead to a lung infection within individuals of every age, yet happens more
abundantly within school-aged kids as well as younger adults. According to the
CDC (Centers for Disease Control and Prevention), mycoplasma leads to more
instances of pneumonia within school-aged kids than all other infections.
Infection happens following your child coming within contact with the
respiratory fluids of the individual who is infected, oftentimes through
coughing and sneezing; the incubation duration might last up to 4 weeks.
The Symptoms
The symptoms of mycoplasma usually occur following the incubation duration of
an infection. Kids underneath the age of five oftentimes show either very mild
symptoms or no symptoms at all, according to the Maryland Community Health
Administration. The symptoms oftentimes involve sore throat, chest pains,
excess fatigue, headache, a dry cough, fever as well as bronchitis. The
child’s symptoms might last for only 3 days or up to 4 weeks, depending on the
infection’s severity.
The Complications
The mycoplasma infection oftentimes results within pneumonia as well as
infections of the middle ear. Pneumonia that results from the mycoplasma
infection is oftentimes called “walking pneumonia,” since it’s not usually
severe, according to the New York State Department. Be sure to follow the
physician’s treatment instructions perfectly to minimize the child’s
opportunities of having the pneumonia become worse. The middle ear infection
will be characterized by the occurence of ear pain as well as excessive
agitation and must be treated immediately in order to decrease the
opportunities of obtaining loss of hearing.
Treatment and Diagnosis
Depending on the youngster’s symptoms as well as the results of the physical
examintion, a physician might do a blood testing to check the cause of an
infection. If the doctor suspects the mycoplasma pneumonia, he’ll probably
also perform a chest X-ray. As mycoplasma includes a bacterium, the
youngster’s physician will usually utilize an antibiotic for the treatment.
Though antibiotics could relieve the child’s symptoms, the bacteria itself
might stay within the youngster’s throat for weeks. Additional vital comfort
steps involve lots of fluids and rest.
Prevention
Performing excellent hygiene should go a long way within keeping the kid from
getting the mycoplasma infection. Teach the child to wash his hands a lot,
cover his mouth while coughing, as well as utilize a tissue while blowing his
nose. A single huge risk factor of getting the mycoplasma infection will be
crowded conditions like the ones within a school; staying away from crowded
school functions as probable, particularly within the late fall and summer,
decreases the kid’s opportunities of getting the mycoplasma infection.
What is Mycoplasma pneumoniae?
Mycoplasma pneumoniae represents a tiny in its size bacterium that belongs to
the class Mollicutes. The organisms adherent to this class have a peculiar
feature: they do not have a peptidoglycan cell wall that is common for all
other firmicute bacteria. At the same time Mycoplasma pneumoniae possesses a
three layer cell membrane that includes cholesterol compounds, resembling
eukaryotic cells. Since the organisms do not have a cell wall, they are not
prone to the influence of penicillins and other beta-lactam antibiotics that
are known for their ability to damage and eliminate the bacterial cell wall.
Mycoplasma pneumoniae is known for having one of the smallest genomes ever
existed. Its genome includes only 816 kilobase pairs (kbs). There has been
carried out comprehensive description of its genome and proteome. It is known
that there is some unique genetic code it employs. This code turns out to have
more in common with mitochondria than with other bacteria. There is no
cellular machinery that could produce many vital compounds. It means that it
represents an obligate parasite. There can be no mycoplasma that is free-
living. From this point of view, mycoplasma is closer to viruses than to
bacteria.
The spreading of Mycoplasma pneumoniae is carried out in a way of respiratory
droplet transmission. When it gets stuck to the mucosa of a host organism, M.
pneumonia begins to withdraw nutrients, gets larger and replicates with the
help of binary fission. It usually sticks to the mucosa in the upper and lower
respiratory tract. This leads to the development of such diseases as
pharyngitis, bronchitis and pneumonia.
The type of infection that is brought about by this bacterium is called
atypical pneumonia. This is due to the fact that it has a protracted course
and does not produce sputum and causes a number of extra-pulmonary symptoms.
As far as chronic mycoplasma infections are concerned, they have been linked
to the pathogenesis of rheumatoid arthritis and other rheumatological
diseases.
As of now, the results of researches conducted all over the world show that
the diagnosis of Mycoplasma pneumoniae could be considered to be reliable only
when found together with bronchial wall thickening as well as centrilobular
nodules in the CT findings. At the same time, these CT findings have not been
detected in patients, who suffer from progressed severe pneumonia caused by
Mycoplasma pneumoniae.
As effective means of treatment can serve second generation macrolide
antibiotics and second generation quinolones. Severity of the disease caused
by mycoplasma can range from mild to moderate.
Mycoplasma Pneumoniae Infections
There are special tests that represent quantitative and qualitative
immunoassays conducted with the purpose of identifying human antibodies that
are directed against Mycoplasma pneumoniae. This helps to define
immunoglobulin classes individuals possess. This, in turn, gives necessary
information about exposure to pathogen and disease state.
Mycoplasma pneumoniae infections lead to the development of a whole number of
respiratory syndromes. Some of them are ordinary and even trivial, others pose
a danger to a patient’s life. They mainly reveal themselves in the form of
primary atypical pneumonia, pharyngitis and tracheobronchitis. According to
the statistics, around 20% out of the total number of ambulatory cases of
pneumonia that occur in the USA are caused by Mycoplasma pneumoniae infection.
Thus, the frequency of infection is pretty high.
In case of Mycoplasma pneumoniae infections, such as RSV-, Influenza Virus-
infections, the process of the causal agent detection can present significant
difficulties because of the wide range of clinical symptoms, especially when
there is atypical pneumonia. Mycoplasma pneumoniae settles in epithelia of the
trachea, bronchia and bronchiolae. After the initial period that can last for
10—20 days, there appear non-specific symptoms like headache and fever
together with a non-productive, dry cough. With time, the infection can cause
the development of an interstitial pneumonia.
In case of older children and young adults Mycoplasma pneumoniae is held
accountable for approximately 15—20% of ambulant obtained cases of pneumonia.
Super infections with Mycoplasma pneumoniae are considered to be common in
children and go after viral and bacterial infections.
When patients are children under 5, there can be observed no symptoms of
Mycoplasma pneumoniae infections. In some cases the revealed symptoms can be
assigned to mild symptoms of the respiratory tract. Since immunity after
infection is not complete, this can lead to infections being repeated and they
can become even more severe.
As there is usually a wide range of clinical symptoms as well as probable
causal agents, diagnosis should include not only the clinical picture. It is
of great importance to resort to serological and direct detection
methodologies that are necessary for defining the pathogen that is hold
accountable. This will make it possible to use the right medical intervention
strategies.
The CFT has been employed in Mycoplasma pneumoniae diagnosis for a long time
already. At the same time, its disadvantage is low specificity as it works on
the LPS that has the cross-reactive nature. As far as ELISA tests are
concerned, they are more specific in terms of antigen preparations that are
capable of distinguishing immunoglobulin classes. Thus, they produce better
diagnostic value of the results.
Mycoplasma pneumoniae: general information
It is known that Mycoplasma pneumoniae very often leads to community-acquired
pneumonia. In fact, the development of the disease is lengthy and gradual.
The first time Mycoplasma pneumoniae was obtained was in 1898. It was done in
cattle affected by pleuropneumonia. In the year 1938, the first case of man
being affected by mycoplasmal pneumonia was accounted by Reimann. He checked 7
patients in Philadelphia, who had obvious constitutional symptoms, upper and
lower respiratory tract symptoms, and a protracted course with gradual
resolution. Reimann named the disease “primary atypical pneumonia”.
Some years later, in 1943, a new phenomenon was found by Peterson. The
scientist made a discovery of cold agglutinin. He also found high titers of
cold agglutinins in those, who suffered from that type of pneumonia. A year
later, a specific agent was discovered by Eaton. The agent was named after the
scientist. So Eaton’s agent was identified as the main trigger of primary
atypical pneumonia. Initially, it was regarded as a virus. However, in 1961
Eaton’s agent was detected as a Mycoplasma species.
Mycoplasma pneumoniae represents a pleomorphic organism, which is different
from bacteria in a way that it does not have a cell wall. It is also different
from viruses for it does not use a host cell in order to replicate. The
disease is usually accompanied by the prolonged paroxysmal cough, which is
considered to be caused by the inhibition of ciliary movement.
One of the specific characteristics of Mycoplasma pneumoniae is its high
gliding motility as well as peculiar filamentous tips end. These specific
properties enable the organism to hide between cilia inside the respiratory
epithelium. This in the end results in making the respiratory epithelial cells
slough.
Another two qualities the organism possesses are held accountable for its
pathogenicity in humans. Firstly, it is characterized by a selective affinity
for respiratory epithelial cells. Secondly, it is capable of generating
hydrogen peroxide. The latter is the major cause of the initial cell
disruption within the respiratory tract as well as for destroying erythrocyte
membranes.
The pathogenicity of Mycoplasma pneumoniae is proved to be connected with the
activation of inflammatory mediators, such cytokines, for instance.
It should be said that in the majority of cases patients with the pneumonia
recover without developing any serious complications. However, Mycoplasma
pneumoniae sometimes leads to severe pneumonia in children. In addition, it
has been proved lately to be connected with acute chest syndrome that develops
in those patients, who suffer from sickle cell anemia.
Immune response to Mycoplasma pneumoniae
Mycoplasma pneumoniae has protein as well as glycolipid antigens that provoke
antibody responses in those who are affected by the infection. One of the most
common aims pursued by many antibodies generated by the host in response to
the Mycoplasma pneumoniae infection is P1 protein. After an initial infection
the immune system starts quickly generating antibodies. The peak comes in 3 to
6 weeks time. Then a decline is observed that can last for months and even
years. Since the incubation period is rather longish, the response to
antibodies can be observed when the symptoms reveal themselves.
The rise in Mycoplasma pneumoniae-specific IgM in the majority of cases can be
regarded as a sign of severe infection, for it emerges within the first week
of the incubation period and about a couple of weeks before IgG antibody does.
At the same time, it is more applicable in pediatric populations when there is
a minimal chance of repeated exposures. In case with adults who have been
endured infections repeatedly it can happen that they will not have any
reaction to mycoplasma antigens with a quick IgM response. Thus, reinfection
causes an IgG response.
There is also IgA antibody, which is often underestimated and not paid
attention to in the process of diagnosis. However, it can be more efficient in
identifying recent infections in groups of all ages. This type of antibodies
is generated in the early stage of the disease. It is also by a rapid
elevation to peak levels, and decline that happens before that of IgM or IgG.
Apart from Mycoplasma pneumoniae-specific antibodies, there is a whole row of
cross-reactive antibodies that can appear during Mycoplasma pneumoniae
infection. There is an extensive sequence homology of the Mycoplasma
pneumoniae adhesin proteins and glycolipids of the cell membrane with
mammalian tissues. They are able to cause autoimmune disorders that affect
multiple organ systems in a way of creating antibodies against such substances
as myosin, keratin, fibrinogen, brain, liver, kidney, smooth muscle, and lung
tissues.
There are also a number of acid homologies with human CD4 and class II major
histocompatibility complex lymphocyte proteins. They function as producers of
autoreactive antibodies and causers of cellular damage and immune system
suppressors.
Infection caused by Mycoplasma pneumoniae also includes specific T-cell-
mediated immunity. Thus, lymphocytes from persons who have already had the
infection earlier, will be subjected to blast transformation in case of
Mycoplasma pneumoniae. Leukocytes from those who suffer from Mycoplasma
pneumoniae infections will also have chemotaxis symptoms when the organism is
present. In this case, a person will have a response in the form of IFN-
presence in the blood.
How to treat infections caused by Mycoplasma pneumoniae?
It is strange enough that in order to cure a mycoplasma infection caused by
Mycoplasma pneumoniae one should do it via his own immune response,
particularly the complement system. It is known that B-lactam antibiotics are
helpless and useless in this situation. It is connected with the fact that B-
lactams, similar to penicillin, perform their actions only on the cell wall,
which is absent in Mycoplasma pneumoniae. However, polyene antibiotics that
help to combat cholesterols in the membrane of mycoplasma, can also prove
effective in the fight against the plasma membrane of the host cells.
The complement system, we referred to above, represents a cascade of proteins
that is usually presented in the tissue or the blood of a host. It is involved
in antigen-antibody reactions that result in cell lysis.
Membrane attack complex that eradicates the bacteria can be carried out in
four ways: through opsonization, cell lysis, inflammotary response and
chemoattraction of neutrophils.
It is known that it is always better to prevent a disease than to cure it.
Unfortunately, there is too little information about a mycoplasma infection
prevention available so far. There is only one common sense thing that you can
do. It is to wash your hands often and not to be in close contact with those
who have the infection.
It is not necessarily that human hosts affected by Mycoplasma pneumoniae will
cause pneumonia. But the virulence this bacterium possesses is connected with
the lipid-associated membrane proteins that are on the cell surface. The
specific polar tip organelles that is necessary for mediating stickiness to
host cells is presented by an organized interaction between such elements as
designated adhesions, interactive proteins and adherence-accessory proteins.
When adhesions are gathered at the tip of the structure, this enables
mycoplasma to settle in mucous membranes and eukaryotic cell surfaces.
According to some research, particular mycoplasma species can be commensal to
healthy people.
There is also an opinion that Mycoplasma pneumoniae is capable of serving as a
medium for bringing other diseases as well into its immune response
monopolization. There has been observed the emergence of other severe
bacterial as well as viral infections in patients who have Mycoplasma
pneumoniae infection. It is supposed to be caused by the specific environment
that can conducted to other organisms in one of the following ways:
anatomically, physiologically, and/or immunologically. This will, in turn,
lead to invasion and disruption of cells.
BE INFORMED ABOUT PNEUMONIA!
Mycoplasma pneumonia is a respiratory lung infection which is caused by a
bacteria of the same name, Mycoplasma pneumoniae or M. pneumoniae. It is also
recognized as atypical pneumonia or walking pneumonia.
This strain of pneumonia usually presents itself in people younger than 40
years of age. Some studies show that M. pneumoniae shows up in 20-50% of adult
pneumonia cases and even more in the younger school age population. This
infection is most common in summer and fall.
You can spread the mycoplasma germ through droplets from the nose and the
throat and through the sneeze of an infected person. This does not happen
immediately and is believed to need prolonged contact with these infected
people. People that work or live in crowed environments are most at risk. This
includes homeless shelters, factories, institutions and schools. The
contagious period is believed to be 10-14 days. If you have been exposed to
these bacteria, the symptoms will usually occur within 15-30 days. They will
appear slowly over a 2-4 day period.
Some of the typical symptoms of mycoplasma. pneumonia are fever and cough,
sore throat, tiredness, and headache quite often. Some less frequent symptoms
that should not be taken lightly are ear and eye pain, lumps in the neck,
rapid breathing and sometimes a skin rash. These symptoms generally last a
week, but have been known to persist for a month.
If one is suspected of having this pneumonia, a cold agglutinins test is
helpful and may be the only test that is required. But if this test is not
definitive then a thorough medical evaluation will be done which includes a
complete physical exam and chest x-rays. If satisfaction is not reached from
these tests, a complete blood count (CBC), bronchoscopy, sputum culture and
urine test may be ordered.
If you have been diagnosed with mycoplasma pneumonia, the chances that you
will get it again are rare, but occasionally it does happen. It is nice to
know though, that the symptoms are much milder the second time around.
The main treatment for mycoplasma pneumonia is antibiotics such as
erythromycin, or clarithromycin. If the symptoms are mild, antibiotics may not
be recommended. Home treatment of plenty of liquids, plenty of rest and a high
protein diet may be all that is recommended for mild cases.
Most people recover completely from mycoplasma. pneumonia without antibiotics,
but antibiotics speed up the process. At this time there is no known vaccine
prevention for this pneumonia, so the best prevention would be to try to avoid
people and situations where you know the problem may exist. As with many
contagious illnesses, the elderly, people in poor health, and people with poor
immune systems should avoid contact with known mycoplasma pneumonia carriers.
Mycoplasma Pneumoniae
Mycoplasma pneumonia is a specific type of atypical pneumonia. Mycoplasma
pneumonia is a bacterial infection in the respiratory tract and in this case,
it is caused by the bacteria called mycoplasma pneumoniae. This is a
“Community Acquired Pneumonia” which means it is usually caught by being in
public and exposed to others who have the pneumonia. Mycoplasma pneumonia is
considered to be a somewhat mild infection, but the symptoms can linger if the
pneumonia is not treated correctly and quickly.
Pneumonia that is an inflammation in the lungs caused by the bacteria
mycoplasma pneumoniae is sometimes referred to as “walking pneumonia”. Since
the condition is fairly mild, many people go about their daily business, not
realizing they are actually sick. That is the reason it is called walking
pneumonia. This form of pneumonia doesn’t usually confine sufferers to bed,
but it can be annoying and severe because it can last a long time.
Mycoplasma pneumonia can be very contagious. Sneezing, coughing, and even
laughing and talking can cause the bacteria to become airborne. However,
exposure to the bacteria does not necessarily mean you will develop the lung
infection.
Mycoplasma pneumonia most often affects younger people, usually between the
ages of 5 to 16. Two million people a year in the United State contract this
form of pneumonia. The symptoms of mycoplasma pneumonia can take as much as
two weeks to manifest themselves after exposure to the bacteria and the
symptoms resemble those of a common cold. For this reason, treatment is often
delayed. Mycoplasma pneumonia generally starts with the sense that you have no
energy and feeling extremely exhausted. Before this period, the disease does
not show any significant symptoms. Eventually other symptoms will begin to
manifest. The most common symptoms are fever and chills, sweating, difficulty
breathing, sore throat, and sometimes headaches. A dry cough is a very common
symptom. Occasionally, the pneumonia can even cause a rash.
Once you realize that something is wrong you should get to the doctor. A mild
case is generally treated with antibiotics. If after completing the round of
antibiotics prescribed, you are still experiencing the symptoms, the doctor
may give you a stronger prescription or recommend hospitalization.
Bacterial Pneumonia
Bacterial pneumonia is an infection which causes inflammation of the lungs.
Although there are several types of pneumonia such as viral pneumonia and
aspiration pneumonia, the most common pneumonia is caused by a single celled
organism, or bacteria, called streptococcus pneumoniae.
Bacterial pneumonia is easily contracted by the elderly whose immune systems
are weakened due to age or disease. Pneumonia is also more common in babies
under two, because their immune systems are still immature. Individuals with
depressed immune systems due to serious illness, or those who are
malnourished, are also at higher risk. Even the healthiest among us can
contract bacterial pneumonia through our everyday contact with others.
Bacterial pneumonia, if left untreated can cause serious illness and death.
The onset of symptoms can occur abruptly, often within hours of infection, and
can lead to fever above 104 degrees Fahrenheit. Symptoms may include fatigue,
shortness of breathe while resting, blueness of the skin, shaking or chills,
fever, sweating, yellowish or greenish phlegm, and chest pain in either lung
(lobe) where the infection has occurred. Other symptoms may include cough and
even blood-stained sputum.
Individuals who suspect pneumonia should see a doctor immediately. The
physician will most likely listen to their chest, and ask for an x-ray and
samples of blood and phlegm to make a firm diagnosis of the type and cause of
the pneumonia. If the doctor determines you have bacterial pneumonia, he will
prescribe antibiotics orally, or by injection. It is important to follow
through and to take the entire course of antibiotics prescribed. Depending
upon the severity of your illness, he or she may ask you to recover at home
for several weeks, or may admit you to a hospital if you have extreme
breathlessness, or cyanosis (turning blue).
Bacteria is found everywhere – in the air we breathe, on surfaces we touch
such as telephones and desktops – and it even lives in our digestive and
respiratory tracts. A simple way to reduce our chance of infection is by
washing our hands frequently throughout the day. Hands, wrists, and fingers,
should be washed vigorously with warm water and regular soap for at least 20
seconds. Any alcohol-based hand sanitizer or wipe is effective in reducing
germs if soap and water are not readily available.
Other precautions to avoid pneumonia include eating a nutritious diet to boost
immune response, by taking restful sleep, and by exercising to improve lung
function. It is a good idea to quit smoking. Those with COPD, asthma, or with
compromised immune systems, should take extra precautions to avoid contact
with those who have colds and flu, because bacterial pneumonia can easily
follow a viral infection.
It is always a good idea to assist your natural defense mechanisms by taking
good care of your health and by doing a few preventative measures to avoid
becoming ill in the first place. The healthier you are, the better chance you
have, of fighting off the bacterium which cause pneumonia.